Rivaroxaban, the first oral factor Xa inhibitor, is a safe and effective oral anticoagulant with definite pharmaceutical properties. It is the first-line treatment of various thromboembolic disease (TED) in adults. With the increasing demand for anticoagulants in children, rivaroxaban shows great potential in the field of pediatrics. This article collected the latest guidelines and literatures related to rivaroxaban in children aged 0-18, and summarized the epidemiological characteristics of TED, the characteristics of coagulation system, the research in pharmaceutical characteristics and clinical efficacy and safety, so as to provide a basis for the rational use of rivaroxaban in pediatrics.
HOU Wei, FENG Xin, ZHANG Jin-hong, YIN Shu-gang, FANG De-min.
Research Progress of Rivaroxaban in Children with Thromboembolic Diseases[J]. Chinese Pharmaceutical Journal, 2021, 56(4): 270-275 https://doi.org/10.11669/cpj.2021.04.003
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